A man and woman have been rushed to hospital following a serious crash on the Kwinana Freeway in Karnup.
Emergency services were called to the single vehicle crash near Paganoni Road around 11.15pm on Tuesday.
The RAC rescue helicopter airlifted the driver, a 45-year-old man, to Royal Perth Hospital with serious injuries.
A 24-year-old female passenger was also taken to Royal Perth Hospital by ambulance with serious injuries.
Police say inquiries are continuing into the crash.
The Kwinana Freeway was closed in both directions for over five hours causing major delays for motorists on Wednesday morning.

Bushfire readiness takes centre stage at City of Kwinana's free Summer Sounds festival
WA Open Golf Championship to tee off at Secret Harbour Golf Links
Halls Head named WA's most persistent storm damage hotspot
Four illegal e-bikes to be crushed after police crackdown in Halls Head, Falcon
Aboriginal jobs and careers expo to attract 1000 attendees in Rockingham
Firefighters attend Lakelands home after reports of thick smoke
WA Government to ban screen use for younger students as part of six-month trial
Singleton General Store shutdown over illicit tobacco, vape sales
Concerns for missing Bertram woman
