An investigation is underway after three workers suffered chemical burns at Alcoa's alumina refinery in Pinjarra.
Emergency crews, including multiple ambulances, were called to the refinery around 5.20pm on Tuesday.
An Alcoa spokeswoman said the men's burns were a result of a valve failure.
"A valve failure at Alcoa’s Pinjarra Alumina Refinery resulted in three employees being exposed to process material,” the spokeswoman said.
Two of the men had to be airlifted to Fiona Stanley Hospital due to the severity of their burns while the third man was treated at the refinery.
It is understood the chemical was sodium hydroxide, also known as caustic soda.
“The area in question has been isolated and clean-up of the material has commenced," the spokeswoman said.
“An investigation into the cause of the incident is underway and the Department of Mines, Industry Regulation and Safety has been notified.”

Pop-up ice skating rink glides back into Mandurah for winter school holidays
Federal opposition leader Angus Taylor sits down with local business owners in Mandurah
Police search for missing man last seen leaving Rockingham Hospital
West Aussies urged to be on high alert after surge in winter house fires
New $3.4 million boardwalk to be constructed at Lake Clifton thrombolites
City of Mandurah rolls out new tactile bin lids, accessibility stickers to support residents with low vision
Driver dies in hospital after Australind crash
Welfare concerns for woman with dementia last seen in Cooloongup
Charges laid over fatal West Coolup crash
